Friday 26 January 2024

Australia Day

Australia Day is meant to provide a formal recognition of the existence of 'Australia' by commemorating the arrival of the First Fleet in 1788 at Sydney Cove and the raising of the Union Jack flag of Great Britain by the first Governor, Arthur Philip. Prior to 1988, Australia Day was quite innocuous with low key celebrations, if any, announcement of public recongition 'honours' recipients and generally it was taken as a public holiday with little fanfare. Re-enactments of the raising of the Flag attracted as few as 200 people at Sydney Cove and the day largely passed without much activity or interest, apart from those going to the beach if the weather was hot.

From the 1988 Bicentenary onward however that changed and Australia Day became the large event it is now and correspondingly increasingly controversial. With this expansion came renewed debate as to the significance of the event and its relative meaning - for the indigenous community it became a constant reminder of the start of the colonisation; for others it retained a connection to Great Britain when Australia was moving into its own cultural identity; for migrants whom did not come from the United Kingdom, it remained a curiosity but little else. So it does raise the question as to whether this is the most apt date to commemorate Australia as a whole or whether such a day is better suited to other significant events such as Federation Day or ANZAC Day both of which have national significance for the country as a whole.

Federation Day commemorates the then six disparate British colonies becoming a single Commonwealth of Australia on 1 January 1901. There is no single answer to the question of the most appropriate date for Australia Day and public opinion polling continues to show a majority of support remains for leaving the current date in place, albeit that this support is less pronounced now than years ago.  

COVID evolution

The emergence of JN.1 is an evolutionary ‘step change’ in the COVID pandemic. Why is this significant?

Lightspring/Shutterstock
Suman Majumdar, Burnet Institute; Brendan Crabb, Burnet Institute; Emma Pakula, Burnet Institute, and Stuart Turville, UNSW Sydney

Since it was detected in August 2023, the JN.1 variant of COVID has spread widely. It has become dominant in Australia and around the world, driving the biggest COVID wave seen in many jurisdictions for at least the past year.

The World Health Organization (WHO) classified JN.1 as a “variant of interest” in December 2023 and in January strongly stated COVID was a continuing global health threat causing “far too much” preventable disease with worrying potential for long-term health consequences.

JN.1 is significant. First as a pathogen – it’s a surprisingly new-look version of SARS-CoV-2 (the virus that causes COVID) and is rapidly displacing other circulating strains (omicron XBB).

It’s also significant because of what it says about COVID’s evolution. Normally, SARS-CoV-2 variants look quite similar to what was there before, accumulating just a few mutations at a time that give the virus a meaningful advantage over its parent.

However, occasionally, as was the case when omicron (B.1.1.529) arose two years ago, variants emerge seemingly out of the blue that have markedly different characteristics to what was there before. This has significant implications for disease and transmission.

Until now, it wasn’t clear this “step-change” evolution would happen again, especially given the ongoing success of the steadily evolving omicron variants.

JN.1 is so distinct and causing such a wave of new infections that many are wondering whether the WHO will recognise JN.1 as the next variant of concern with its own Greek letter. In any case, with JN.1 we’ve entered a new phase of the pandemic.

Where did JN.1 come from?

The JN.1 (or BA.2.86.1.1) story begins with the emergence of its parent lineage BA.2.86 around mid 2023, which originated from a much earlier (2022) omicron sub-variant BA.2.

Chronic infections that may linger unresolved for months (if not years, in some people) likely play a role in the emergence of these step-change variants.

In chronically infected people, the virus silently tests and eventually retains many mutations that help it avoid immunity and survive in that person. For BA.2.86, this resulted in more than 30 mutations of the spike protein (a protein on the surface of SARS-CoV-2 that allows it to attach to our cells).

The sheer volume of infections occurring globally sets the scene for major viral evolution. SARS-CoV-2 continues to have a very high rate of mutation. Accordingly, JN.1 itself is already mutating and evolving quickly.

How is JN.1 different to other variants?

BA.2.86 and now JN.1 are behaving in a manner that looks unique in laboratory studies in two ways.

The first relates to how the virus evades immunity. JN.1 has inherited more than 30 mutations in its spike protein. It also acquired a new mutation, L455S, which further decreases the ability of antibodies (one part of the immune system’s protective response) to bind to the virus and prevent infection.

The second involves changes to the way JN.1 enters and replicates in our cells. Without delving in to the molecular details, recent high-profile lab-based research from the United States and Europe observed BA.2.86 to enter cells from the lung in a similar way to pre-omicron variants like delta. However, in contrast, preliminary work by Australia’s Kirby Institute using different techniques finds replication characteristics that are aligned better with omicron lineages.

Further research to resolve these different cell entry findings is important because it has implications for where the virus may prefer to replicate in the body, which could affect disease severity and transmission.

Whatever the case, these findings show JN.1 (and SARS-CoV-2 in general) can not only navigate its way around our immune system, but is finding new ways to infect cells and transmit effectively. We need to further study how this plays out in people and how it affects clinical outcomes.

Is JN.1 more severe?

A woman in a supermarket wearing a mask.
JN.1 has some characteristics which distinguish it from other variants. Elizaveta Galitckaia/Shutterstock

The step-change evolution of BA.2.86, combined with the immune-evading features in JN.1, has given the virus a global growth advantage well beyond the XBB.1-based lineages we faced in 2023.

Despite these features, evidence suggests our adaptive immune system could still recognise and respond to BA.286 and JN.1 effectively. Updated monovalent vaccines, tests and treatments remain effective against JN.1.

There are two elements to “severity”: first if it is more “intrinsically” severe (worse illness with an infection in the absence of any immunity) and second if the virus has greater transmission, causing greater illness and deaths, simply because it infects more people. The latter is certainly the case with JN.1.

What next?

We simply don’t know if this virus is on an evolutionary track to becoming the “next common cold” or not, nor have any idea of what that timeframe might be. While examining the trajectories of four historic coronaviruses could give us a glimpse of where we may be heading, this should be considered as just one possible path. The emergence of JN.1 underlines that we are experiencing a continuing epidemic with COVID and that looks like the way forward for the foreseeable future.

We are now in a new pandemic phase: post-emergency. Yet COVID remains the major infectious disease causing harm globally, from both acute infections and long COVID. At a societal and an individual level we need to re-think the risks of accepting wave after wave of infection.

Altogether, this underscores the importance of comprehensive strategies to reduce COVID transmission and impacts, with the least imposition (such as clean indoor air interventions).

People are advised to continue to take active steps to protect themselves and those around them.

For better pandemic preparedness for emerging threats and an improved response to the current one it is crucial we continue global surveillance. The low representation of low- and middle- income countries is a concerning blind-spot. Intensified research is also crucial.The Conversation

Suman Majumdar, Associate Professor and Chief Health Officer - COVID and Health Emergencies, Burnet Institute; Brendan Crabb, Director and CEO, Burnet Institute; Emma Pakula, Senior Research and Policy Officer, Burnet Institute, and Stuart Turville, Associate Professor, Immunovirology and Pathogenesis Program, Kirby Institute, UNSW Sydney

This article is republished from The Conversation under a Creative Commons license. Read the original article.

Tuesday 16 January 2024

The warming of Antarctica

DM Bergstrom, Author provided

A heatwave in Antarctica totally blew the minds of scientists. They set out to decipher it – and here are the results

Dana M Bergstrom, University of Wollongong

Climate scientists don’t like surprises. It means our deep understanding of how the climate works isn’t quite as complete as we need. But unfortunately, as climate change worsens, surprises and unprecedented events keep happening.

In March 2022, Antarctica experienced an extraordinary heatwave. Large swathes of East Antarctica experienced temperatures up to 40°C (72°F) above normal, shattering temperature records. It was the most intense heatwave ever recorded anywhere in the world.

So shocking and rare was the event, it blew the minds of the Antarctic climate science community. A major global research project was launched to unravel the reasons behind it and the damage it caused. A team of 54 researchers, including me, delved into the intricacies of the phenomenon. The team was led by Swiss climatologist Jonathan Wille, and involved experts from 14 countries. The collaboration resulted in two groundbreaking papers published today.

The results are alarming. But they provide scientists a deeper understanding of the links between the tropics and Antarctica – and give the global community a chance to prepare for what a warmer world may bring.

Head-hurting complexity

The papers tell a complex story that began half a world away from Antarctica. Under La NiƱa conditions, tropical heat near Indonesia poured into the skies above the Indian Ocean. At the same time, repeated weather troughs pulsing eastwards were generating from southern Africa. These factors combined into a late, Indian Ocean tropical cyclone season.

Between late February and late March 2022, 12 tropical storms had brewed. Five storms revved up to become tropical cyclones, and heat and moisture from some of these cyclones mashed together. A meandering jet stream picked up this air and swiftly transported it vast distances across the planet to Antarctica.

Below Australia, this jet stream also contributed to blocking the eastward passage of a high pressure system. When the tropical air collided with this so-called “blocking high”, it caused the most intense atmospheric river ever observed over East Antarctica. This propelled the tropical heat and moisture southward into the heart of the Antarctic continent.

Luck was on Antarctica’s side

The event caused the vulnerable Conger Ice Shelf to finally collapse. But the impacts were otherwise not as bad as they could have been. That’s because the heatwave struck in March, the month when Antarctica transitions to its dark, extremely cold winter. If a future heatwave arrives in summer – which is more likely under climate change – the results could be catastrophic.

Despite the heatwave, most inland temperatures stayed below zero. The spike included a new all-time temperature high of -9.4°C (15.1°F) on March 18 near Antarctica’s Concordia Research Station. To understand the immensity of this, consider that the previous March maximum temperature at this location was -27.6°C (-17.68°F). At the heatwave’s peak, 3.3 million square kilometres in East Antarctica – an area about the size of India – was affected by the heatwave.

The impacts included widespread rain and surface melt along coastal areas. But inland, the tropical moisture fell as snow – lots and lots of snow. Interestingly, the weight of the snow offset ice loss in Antarctica for the year. This delivered a temporary reprieve from Antarctica’s contribution to global sea-level rise.

An ice shelf before (left) and after (right) a collapse.
These images, acquired by the Copernicus Sentinel-2 satellites on January 30 2022 (left) and March 21 2022 (right), show the Conger ice shelf before and after the collapse, which was triggered by a shocking heatwave. European Union, Copernicus Sentinel-2 satellite imagery, CC BY

Learning from the results

So what are the lessons here? Let’s begin with the nice bit. The study was made possible by international collaboration across Antarctica’s scientific community, including the open sharing of datasets. This collaboration is a touchstone of the Antarctic Treaty. It serves as a testament to the significance of peaceful international cooperation and should be celebrated.

Less heartwarmingly, the extraordinary heatwave shows how compounding weather events in the tropics can affect the vast Antarctic ice sheet. The heatwave further reduced the extent of sea ice, which was already at record lows. This loss of sea ice was exacerbated this year resulting in the lowest summer and winter sea ice ever recorded. It shows how disturbances in one year can compound in later years.

The event also demonstrated how tropical heat can trigger the collapse of unstable ice shelves. Floating ice shelves don’t contribute to global sea-level rise, but they acts as dams to the ice sheets behind them, which do contribute.

This research calculated that such temperature anomalies occur in Antarctica about once a century, but concluded that under climate change, they will occur more frequently.

The findings enable the global community to improve its planning for various scenarios. For example, if a heatwave of similar magnitude hit in summer, how much ice melt would there be? If an atmospheric river hit the Doomsday glacier in the West Antarctic, what rate of sea level rise would that trigger? And how can governments across the world prepare coastal communities for sea level rise greater than currently calculated?

This research contributes another piece to the complex jigsaw puzzle of climate change. And reminds us all, that delays to action on climate change will raise the price we pay.

This article has been amended to correct an error in converting a 40°C temperature difference from Celsius to Fahrenheit.The Conversation

Dana M Bergstrom, Honorary Senior Fellow, University of Wollongong

This article is republished from The Conversation under a Creative Commons license. Read the original article.